Nobilis® IB 4-91

This vaccine may only be used by persons registered in terms of or authorised in terms of section 23 (1) (c) of the Veterinary and Para-Veterinary Professions Act, 1982 (Act No. 19 of 1982).

Learn more about Infectious Bronchitis in chickens by visiting our dedicated website here.



Reg. No. G4031 (Act 36/1947)

Namibia Reg. No. V13/24.3/1200 NS0

This vaccine may only be used by persons registered in terms of or authorised in terms of section 23 (1) (c) of the Veterinary and Para-Veterinary Professions Act, 1982 (Act No. 19 of 1982).


Nobilis® IB 4-91 is a live attenuated, freeze-dried vaccine against Infectious Bronchitis virus serotype 4-91 or serologically related types for administration to 1-day-old chicks and older chickens (broilers, breeders, layers).


Each dose contains at least log10 3,6 EID50 of live attenuated avian Infectious Bronchitis Virus (IBV) strain 4-91 in stabiliser.


After vaccination, an adequate immunity against Infectious Bronchitis serotype 4-91 and serologically related serotypes will last for at least 6 weeks, provided that the vaccine is properly administered. Immunogenicity of the vaccine antigen will be reduced by poor storage or inappropriate administration.

For further information on use of a vaccine in specific circumstances, or in conjunction with other Intervet South Africa vaccines, consult Intervet South Africa (Pty) Ltd. technical staff.



  • Meat – Do not vaccinate within 21 days of slaughter.


  • is intended to protect chickens against IBV serotype 4-91 and related types only. Chickens should be vaccinated against other prevalent IBV serotypes (e.g., Massachusetts) according to the local IB vaccination programme.
  • given to 1-day-old chicks adversely affect the efficacy of Turkey Rhinotracheitis (TRT) vaccine when given within 7 days; thus, TRT should not be used within 14 days of Nobilis® IB 4-91.


Do not open and reconstitute the vaccine until ready to start vaccination.

Reconstituted vaccine should be used within 2 hours after reconstitution.

Recommended Vaccination Programme

The vaccine can be administered to 1-day-old chicks and older chickens by coarse spray or via intranasal/ocular administration.

The vaccine can be administered to chickens of 7 days and older, via drinking water.

For prolonged immunity, chickens should be revaccinated 6 weeks after the initial administration.

Dosage and Administration

The vaccine may be delivered as a lyophilised pellet in a glass vial or as lyophilised spheres in cups.

At least 3,6 log10 EID50 (1 dose) per animal by coarse spray, drinking water or intranasal/ocular drop administration.

Where the number of chickens is between the standard dosages, the next higher dosage should be used.

The optimum time and method of administration depend largely upon the local situation and veterinary advice should be sought on a site basis.

The vaccine may be administered by coarse spray, drinking water or via the intranasal/ocular route.

Reconstitution of vaccine

Volumes of water for reconstitution of vaccine

The volume of water for reconstitution depends on the age of the birds and the management practice.

Simple drinking troughs and fountains

The following are guidelines: 1 000 doses/ℓ per age in days up to a maximum volume of

20 ℓ/1 000 doses. For heavy breeds, or in hot weather, the quantity of water may be increased up to 30 ℓ/1 000 doses.

Nipple drinkers

Drinker line management is known to have a significant effect on the viability of live vaccine virus.

The vaccine virus can deteriorate very rapidly, and it is essential to ensure that all birds receive the correct dose.

Special care should be taken concerning the method of administration, for example, small header tanks may require recharging with medicated water several times during a 1 to 2 hour period.


Water should be withheld before vaccination.

For recommendations, see Management below.

Ensure that all the vaccine suspension is consumed within 1 to 2 hours.

Turn on main water when all the vaccine water has been consumed.

Always ensure that there is feed available when vaccinating. Birds will not drink if they have no feed to eat. Water intake is directly correlated to feed intake.


Great care should be taken to ensure that all birds receive a full dose of vaccine when the product is administered.

The following points have been found to improve vaccine “take”:

Note: Administration by coarse spray or the intranasal/ocular method gives the best response. These should be the methods of choice, especially when vaccinating young chicks.

The vaccine can be administered through the drinking water.

The vaccine should be dissolved in an amount of water which will be consumed by the chickens within approximately 2 hours.

Guideline when Nobilis® IB 4-91 is used with Nobilis® IB Ma5

The instruction on reconstitution of both lyophilisates and the subsequent application are to be followed as outlined above for spray and intranasal/ocular administration. The same volumes as for the single product should be used.


Vaccination with Nobilis® IB 4-91 may induce a mild respiratory reaction for a few days and is dependent on the health and condition of the birds. Good hygiene and management are also important factors in order to minimise vaccination reactions.


Type I glass vials containing 1 000, 2 500, 5 000 or 10 000 doses of vaccine as a freeze-dried pellet.

Sealed aluminium laminate cups containing 1 000, 2 500, 5 000 or 10 000 doses as freeze-dried sphereons.

Not all pack sizes may necessarily be marketed.

REGISTRATION HOLDER                                        

Intervet South Africa (Pty) Ltd.                                   

20 Spartan Road, Spartan                                          

1619, RSA                                                                  

Tel: +27 (0) 11 923 9300                                             



29 November 2021

Zimbabwe Reg. No. E2014/80.23.17/9703 Pharmacological Classification 80.23.17 Distribution Category VMGD