Product Details - SOLUTION® 3,5 % L.A.


Solution 3,5% LA



Reg. No. G3689 (Act 36/1947)
Namibia Reg. No. V06/18.1.2/651 NS0

An antiparasitic remedy for cattle, horses, donkeys and sheep.

Contains Ivermectin* 2,25 % m/v and Abamectin* 1,25 % m/v.
* Macrocyclic Lactone



  • Store in a cool, dry place below 25 °C.
  • Protect from exposure to direct sunlight and moisture.


  • Withdrawal period: Cattle must not be slaughtered for human consumption within 120 days of last treatment. Sheep must not be slaughtered for human consumption within 70 days of last treatment.
  • Do not use in dairy cattle.
  • Do not administer to calves less than 16 weeks of age.
  • Can safely be used in lambs weighing 10 kg or more.
  • Do not administer intravenously or intramuscularly.
  • Dispose of empty containers according to local waste disposal regulations and do not reuse for any other purpose.
  • Although this remedy has been tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.


  • Vaccination of cattle against Clostridium infections (e.g. black quarter) prior to the treatment with Solution® 3,5% LA is recommended.
  • Sheep should be vaccinated against pulpy kidney (enterotoxaemia) before treatment.
  • Do not smoke or eat while handling the product.
  • Wash hands after use.
  • Store bottle in carton to protect from light.
  • N.B. Transitory discomfort has been observed in some animals following subcutaneous administration.
  • A low incidence of soft tissue swelling may be observed at the injection site. These reactions are normal and usually resolve without treatment.

Studies indicate that when Ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time. Drug containers and any residual content should be disposed of safely in accordance with waste disposal regulations as free ivermectin may adversely affect fish and certain waterborne organisms.


  • Solution® 3,5% LA should be given subcutaneously as a single dose at the recommended dosage level of 1 mℓ per 50 kg body mass (450 µg ivermectin per kg body mass, 250 µg abamectin per kg body mass).
  • Use sterile equipment and follow aseptic procedures. Do not dilute or mix with any other product.
  • Use a sterile needle for each horse to be injected.

Subcutaneous Injection Technique
The correct position and administration of this product is important to avoid muscular damage to the brachiocephalic, sternocephalic or trapezius muscles. A method to ensure that the injection is given subcutaneously and adequately superficial to the underlying neck muscles follows:

  1. Place your hand flat on the horse's neck just behind the halter.
  2. Slide your hand down the neck towards the shoulder blade.
  3. Stop when you reach the front of the shoulder.
  4. The area adjacent to your flat hand (opposite to the edge of your hand against the shoulder) offers relatively more loose skin which will be sufficient for the purpose of the injection. The injection is to be administered under the skin and not in the muscle.
  5. The injection should be given in the last third of the neck, in the middle of the side of the neck area (halfway between the top and bottom of the neck) as to avoid the 2 main superficial muscles i.e. brachiocephalic and trapezius. The diagrams below offer guidance:

    SOLUTION® 3,5 % L.A. - Indications
  6. It is absolutely imperative that we ensure the skin is lifted sufficiently to create a subcutaneous pocket within which the product will be injected, and the underlying muscles will be avoided and preserved. See diagram above.
  7. Using a new needle and syringe, penetrate the skin with the needle at an acute angle (almost parallel to the neck) in order to enter the subcutaneous pocket created with your other hand lifting the skin.
  8. Depress the plunger of the syringe slowly and inject the contents of the syringe subcutaneously. Solution® 3,5% LA is an oil-based liquid given at relatively large volumes subcutaneously and will be absorbed slower than an aqueous based liquid, hence creating a visible lump on the animal’s neck which will generally disappear naturally and without any discomfort to the animal over the next few days i.e. it is self-limiting and does not require any treatment. Rub well after having injected the contents of the syringe as it aids the absorption process. Take care not to inject into your fingers or that you push the needle in so much that it comes out on the other side of the skin fold.

Inadvertent intramuscular injections are very common due to the superficial nature of the equine neck muscles, as well as the sensitive nature of equine musculature. The consequences of intramuscular administration are:

  • Slower absorption of injected liquid which will be visible for a longer period of time on the skin as a lump (this is especially important in animals used for show purposes - make sure to administer well in advance of such shows e.g. 1 month)
  • Potential lameness as a result of muscular pain (brachiocephalic and trapezius being the most commonly affected muscles) - once again, this is especially important in animals used for performance events like show jumping, endurance, racing, etc. Make sure to administer treatment well in advance of such performance events e.g. 1 month.


MassDose volume
50 kg1 mℓ
51 - 100 kg2 mℓ
101 - 150 kg3 mℓ
151 - 200 kg4 mℓ
201 - 250 kg5 mℓ
251 - 300 kg6 mℓ
301 - 350 kg7 mℓ
351 - 400 kg8 mℓ
401 - 450 kg9 mℓ
451 - 500 kg10 mℓ
501 - 550 kg11 mℓ
551 - 600 kg12 mℓ


Roundworm species 

Gastro-intestinal nematode speciesImmatureAdultResidual activity #
(Haemonchus placei)
**49 days
Brown stomach worm
(Ostertagia ostertagi)
**56 days
Cattle bankrupt worm
(Cooperia spp.)
**42 days
(Bunostomum phlebotomum)
**56 days
Nodular worm
(Oesophagostomum radiatum)
**56 days
Lung nematode species   
(Dictyocaulus viviparous)


Gastro-intestinal nematode speciesImmatureAdult 
Stomach worm
Draschia megastoma,
Habronema spp.
Small strongyles
Cyathostomum coronatum, C.tetracantum, C. labiatum, C. labratum;
Cyclicocyclus insigne, C. elongates;
Cyclicodontophorus spp.
Cylicostephanus minutus, C. calicatus, C. longibursatus, C. goldi;
Triodontophorus serratus, Triodontophorus spp.
Large strongyles
Strongylus edentatus, S. equinus, S. vulgaris
Oxyuris equi
Parasitic fly speciesImmatureAdult
Common horse bot
Gasterophilus spp.



Haemonchus contortus


Bankrupt worm
Trichostrongylus colubriformis


* Controls (> 90 % effective)
# Period between treatment and reinfestation

Tick species

CattleControls and prevents reinfestation for
Blue ticks
(Boophilus spp.)
54 days *

* (> 90 % effective)

Ectoparasitic mite species

SheepKills and prevents reinfestation for
Sheep scab mites
Psoroptes communis ovis
56 days

Kills sheep scab mites and controls an outbreak with a single injection.
** All sheep that are injected must be marked to ensure all sheep have been injected.

50 mℓ and 500 mℓ vials.
The vials are amber glass vials with a bromobutyl rubber stopper held in place with an aluminium flip-of seal, fitted in a polyethylene cover and packed in a carton outer container.

Intervet South Africa (Pty) Ltd.
20 Spartan Road, Spartan
1619, RSA
Tel: +27 (0) 11 923 9300
Fax: +27 (0) 11 392 3158

Burchem Research (Pty) Ltd
54 Electron Avenue

5 March 2014