Product Details - NOBILIS® CAV P4


Product Class

For Animal Use Only
Reg. No.G2467 (Act 36/1947)
Namibia Reg No: V09/24.3/673 S0

NOBILIS® CAV P4 is intended for the immunisation of healthy future breeding fowls against chicken anemia.


  • Store in the dark between 2 ºC and 8 ºC. Do not freeze.
  • Avoid prolonged or repetitive exposure to high ambient temperatures following withdrawal from the refrigerator prior to use.
  • Protect from direct sunlight.
  • The diluent may be stored at room temperature between 20 ºC and 25 ºC prior to use

This is a live attenuated freeze-dried vaccine containing chicken anaemia vaccine virus.

Each 1 ml dose contains at least 2,3 log TCID50 of chicken anemia vaccine virus propagated on embryonated eggs. The freeze-dried pellet contains stabilisers.


  • The vaccine must not be administered to fowls below 6 weeks of age.
  • Breeding fowls have to be vaccinated at least 6 weeks before the onset of lay.
  • Do not freeze.
  • It is advisable to vaccinate all the susceptible fowls on the farm at the same time. If this is not feasible, strict separation of vaccinated and unvaccinated fowls should be done to prevent the spread of the vaccine virus to the unvaccinated fowls.
  • Destroy any unused, reconstituted vaccine, empty vaccine containers, needles, etc. for instance by burning after completion of the vaccination.
  • Wash and disinfect hands and equipment after vaccinating.
  • Do not open and reconstitute the vaccine until ready to start vaccination.
  • Use the vaccine immediately after reconstitution.
  • Do not store partially used containers for future use.
  • Use according to the number of doses as indicated on the label.
  • Keep out of reach of children and uninformed persons.
  • Although this vaccine has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.


  • Only healthy fowls should be vaccinated.
  • Observe aseptic precautions. Ensure that all vaccination equipment (needles, syringes, etc.) are clean and sterile before use.
  • The vaccination equipment used should be free from traces of disinfectant or spirit.
  • Ensure that all equipment is kept clean and sterile during use.
  • Each vial should be used immediately after opening.
  • Avoid intravenous injection.
  • It is good vaccination practice to avoid contact with the eyes, hands and clothing when handling the vaccine.

A. Intramuscular and Subcutaneous Injection

  • Reconstitute the vaccine with Intervet’s diluent, Diluent 251258.
  • Add some of the diluent to the vial of the vaccine, using a sterile syringe and needle, and shake. Withdraw the rehydrated vaccine into the syringe and add the rest of the diluent. Gently shake to mix. Withdraw a portion of the diluent to flush the vial and inject the fluid back into the diluent bottle. Remove the syringe. Fill the automatic syringe according to the manufacturers recommendation and set the dose to 0,2 ml.
  • Dosage: 0,2 ml contains 1 fowl dose (The amount of diluent to be used depends on the number of doses per vial) Administer the vaccine by intramuscular or subcutaneous route.

B. Application by the Wing-web method

  • Reconstitute the vaccine with the appropriate amount of diluent.
  • The vaccine is supplied with 200 ml diluent and a double needle.
  • After reconstitution of the vaccine with the diluent the wing-web needle is dipped into the vaccine solution, before the vaccination of each fowl, so that both grooves are filled. The needle is inserted through the wing-web from beneath, taking care to avoid the feathered parts of the web. 7 to 10 days past vaccination the reaction should be examined in a certain number of fowls. The site of vaccination should show minor swelling and small scabs which will disappear within 2 to 3 weeks.

Vaccination Program
The optimum time and method of administration depend largely upon the local situation. Therefore the advice of a veterinarian should be sought. Under no circumstances should the vaccine be administered below 6 weeks of age. To make sure that adequate antibody levels are built up at the onset of lay, breeding fowls have to be vaccinated at least 6 weeks before this onset. Vaccination against CAV can be combined with vaccination against Reo (intramuscular or subcutaneous route) or with vaccination against Fowl Pox (wing-web route)

The induction of high neutralising antibody levels is generally dependant on the health and indication of the fowls. Hygiene and management are also important in the post-vaccination period. Breeding fowls must be vaccinated at least 6 weeks before the onset of lay.

Boxes containing 10 vials of 1 000 doses each with Diluent 251258 and wing-web needle.

Registration Holder
Intervet South Africa.(Pty) Ltd.
20 Spartan Road
Tel: +27 (0) 11 923 9300
Fax: +27 (0) 11 392 3158